Understanding antibiotic resistance via outer membrane permeability
نویسندگان
چکیده
منابع مشابه
Alterations in outer membrane permeability.
INTRODucnON ... ......... ........... .. . .. ........ ... ........ . .. .. ... .. ... . ......... .. ........ . 238 Structure oj the Cell Envelope.................................................................. 238 Uptake Arross the Outer Membrane.......................................................... 239 Intrinsic,Dejects in Outer Membrane Permeability in So.me Bacteria . .... ..... .. ....
متن کاملAmelioration of the Fitness Costs of Antibiotic Resistance Due To Reduced Outer Membrane Permeability by Upregulation of Alternative Porins.
The fitness cost of antibiotic resistance is a key parameter in determining the evolutionary success of resistant bacteria. Studies of the effect of antibiotic resistance on bacterial fitness are heavily biased toward target alterations. Here we investigated how the costs in the form of a severely impaired growth rate associated with resistance due to absence of two major outer membrane porins ...
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Background & Objectives: Pseudomonas aeruginosa is a common cause of nosocomial infection. OprD protein is a specific protein regulating the uptake of carbapenem antibiotic. Loss of OprD is the main mechanism of Pseudomonas Aeruginosa resistance to carbapenem. In this study, the presence of OprD gene is investigated in isolated Pseudomonas Aeruginosa in burn patients of Ghotboddin hospital in S...
متن کاملMolecular basis of bacterial outer membrane permeability.
INTRODUCTION Bacteria produce cell walls with the exception of mycoplasmas, and the cell wall component common to all eubacteria is the murein, or the peptidoglycan, which contributes mechanical rigidity. All gram-negative bacteria contain an additional layer in the cell wall structure, i.e., the outer membrane, which is located outside the peptidoglycan layer and shows up as a trilaminar struc...
متن کاملRole of porins in outer membrane permeability.
It is now well recognized that the outer membranes of gram-negative bacteria serve as molecular sieves which permit the passage of small hydrophilic molecules of sizes below a given cutoff, i.e., the exclusion limit (21, 27). This sieving property, which permits uptake of small substrate molecules but excludes potentially harmful enzymes and other large hydrophilic molecules, is due to a class ...
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ژورنال
عنوان ژورنال: Infection and Drug Resistance
سال: 2018
ISSN: 1178-6973
DOI: 10.2147/idr.s156995